TABLE 1.

Effect of immunization on survival of mice challenged with C. neoformansa

Exp.Median no. of survival days
PBSAdjuvantCRMPFT
1710261822
210142624NDb
31114232464
4ND7ND1821
Combined911252136
  • a Groups of 8 to 10 C57BL/6J mice received two i.p. injections 3 weeks apart of PBS, Ribi adjuvant system without antigen (Adjuvant) or Ribi adjuvant system admixed with 100 μg of CR, MP, or FT antigen. One week following the last injection, mice received an i.v. challenge of 106 live C. neoformans cells. Mice were monitored for signs of disease and sacrificed when signs of disease were severe.

  • b ND, not determined.