TABLE 5.

Purified rLP2086 from subfamily A or subfamily B elicits bactericidal antibodies in mice which are bactericidal against several strains of serogroup B N. meningitidis

AntigenTitera
Subfamily B test strainsSubfamily A test strains
H44/7688004915736940M982870446M98 250771M98 250732M97 252697
Subfamily B
    rLP2086-85293,200400<25>800200800<25
    rLP2086-880049400>800100400200400
    rLP2086-1573200>80080020010050
    rLP2086-M982>800>800<25200>800400
Subfamily A
    rLP2086-2996<25>800800>800>800
    rLP2086-870446>800400400400
    rLP2086-250771>800>800>800>800
    rLP2086-252988>800>800>800>800
    rLP2086-C11>800200200400
  • a Bactericidal (BC50) titers represented as the reciprocal of the dilution of antiserum that reduced viable cell count by 50%. Week 0 normal mouse sera had BC50 titers of <50. A dash indicates samples were not tested.