Purified rLP2086 from subfamily A or subfamily B elicits bactericidal antibodies in mice which are bactericidal against several strains of serogroup B N. meningitidis

Subfamily B test strainsSubfamily A test strains
H44/7688004915736940M982870446M98 250771M98 250732M97 252697
Subfamily B
Subfamily A
  • a Bactericidal (BC50) titers represented as the reciprocal of the dilution of antiserum that reduced viable cell count by 50%. Week 0 normal mouse sera had BC50 titers of <50. A dash indicates samples were not tested.