TABLE 2.

Effect of intravenous injection of fusobacteria on pregnancy outcome in mice

F. nucleatum strainDose (CFU)No. of mice infectedNo. of pups deliveredaNo. of dead pupsa,bDeath ratec (%)LD50 (CFU)d
122304 × 105349364 × 107
2 × 1078872023
4 × 107121267761
7 × 1076635993
12230 lam4 × 106330006 × 107
2 × 10753339
4 × 107435720
1 × 10843636100
29298 × 10689118202 × 107
1 × 1074473268
3 × 1074442761
  • a Values shown were combined for all mice infected with the same dose.

  • b Includes premature births and term stillbirths.

  • c The death rate was calculated as (number of dead pups)/(number of pups delivered) × 100. The dead pup values include all pups delivered dead, either at term or prematurely, and those that died after delivery.

  • d The LD50 was determined as the dose that resulted in a fetal death rate of 50% and was calculated as described in Materials and Methods.