TABLE 6.

Antisera from mice immunized with mixtures of rLP2086 variants and rPorA are bactericidal against multiple strains of serogroup B meningococcal strains

Test strainBactericidal titer
rLP2086 monovalent controlarPorA monovalent controlbrLP2086-8529 + rLP2086-2996rLP2086-8529 + rLP2086-2996 + rP1.22-1,14 + rP1.5-1,2-2
H44/76>800>800>800
6940>800>800800
880049200200100
M982400400200
870446>800>800>800
M98 250771800800400
M98 250732>800>800400
M97 252697>800>800>800
6557<25800<25200
NMB<25>800>800
  • a The monovalent control for subfamily B strains H44/76, 6940, 880049, and M982 was mouse antiserum raised against rLP2086-8529, and the monovalent control for subfamily A strains 870446, M98 250771, M98 250732, M97 252697, 6557, and NMB was mouse antiserum raised against rLP2086-2996.

  • b The rPorA monovalent control for strain 6557 was mouse antiserum raised against rP1.22-1,14-1, and the monovalent control for NMB was mouse antiserum raised against rP1.5-1,2-2. A dash indicates samples were not tested.