TABLE 2.

Demand theorya of L. pneumophila differentiation

Growth phaseDemand for transmission genesPredicted mode of regulationRegulatorsObserved mode of regulationReference(s)
E (replicative)LowNegativeRpoS, CsrANegativeThis work, 17, 43
PE (transmissive)HighPositiveRpoS, LetA/S, LetE, FliAPositiveThis work, 3, 12, 20, 22, 27, 29, 41, 43
  • a See Discussion and references 47, 54, and 55.