TABLE 1.

Increase in antigen-specific IgG responses following skin test application

AnimalIncrease in IgG responsea to:
ESAT-6MPB70MPB83MBCF
Controls
    C10.0012.00149.2428.40
    C20.002.3235.950.50
    C318.180.0036.916.38
    C46.262.3049.590.00
    C52.232.0098.7716.00
    C63.4612.2069.68−12.50
        Mean5.025.1473.366.46
BCG vaccinated
    B120.680.0041.894.18
    B20.000.00−7.610.86
    B30.001.270.004.06
    B40.000.000.00−3.86
    B50.000.000.0014.70
    B60.000.000.000.00
        Mean3.450.215.713.32
  • a Data are expressed as relative density units and were calculated by subtracting values obtained by MAPIA analysis of sera taken before the skin test (week 27) from values obtained post-skin test (week 31). The tuberculin skin test was performed during week 28. P values for differences between control and BCG-vaccinated animals were 0.730 for ESAT-6 (by an unpaired, two-tailed t test), 0.079 for MPB70, 0.013 for MPB83, and 0.495 for MBCF. For the latter three P values, an unpaired, two-tailed t test with the Welch correction was used.