TABLE 3.

Phenotypic characteristics of strains recovered in vitroa

StrainDoubling time (h)Capsule thickness (μm)cMIC of drug for strainbCapsule structure
ITZFCZAmBFluorescence intensity (MdF)Heterogeneity of cell population (CVF)
C.0.14.10.12 ± 0.00NDNDND7.2209
C.0.24.00.16 ± 0.05NDNDND3.8225
C.0.33.70.13 ± 0.17NDNDND8.7194
C.0.43.70.17 ± 0.06NDNDND8.8203
C.0.53.80.17 ± 0.07NDNDND12.5215
C.1.14.10.19 ± 0.060.12580.515.5202
C.1.23.80.21 ± 0.040.12580.521.5192
C.1.34.00.16 ± 0.060.12580.523.3172
C.1.44.20.21 ± 0.070.12580.516.7198
C.1.53.50.23 ± 0.060.0640.525.8178
C.8.14.60.19 ± 0.060.12580.520.4182
C.8.24.00.20 ± 0.060.12580.523.4190
C.8.33.70.20 ± 0.060.12540.522.8183
C.8.43.20.21 ± 0.050.12540.521.8184
C.8.53.70.22 ± 0.060.12540.530.2156
C.35.14.10.25 ± 0.100.25080.586.4100
C.35.23.90.19 ± 0.070.12540.510.7220
C.35.33.70.23 ± 0.060.12540.558.9144
C.35.44.00.22 ± 0.060.0640.525.9148
C.35.54.20.22 ± 0.060.0680.514.1211
  • a Different phenotypes of the strains recovered from cultures after day 1 (C.1.X), day 8 day (C.8.X), and day 35 (C.35.X) were studied.

  • b ITZ, itraconazole; FCZ, fluconazole; AmB, amphotericin B. ND, not determined.

  • c Data are means ± SD.