TABLE 2.

Phenotypic characteristics of strains recovered from the brainc

StrainDoubling time (h)Capsule thickness (μm)bMIC of drug for strainaCapsule structure
ITZFCZAmBFluorescence intensity (MdF)Heterogeneity of cell population (CVF)
B.1.15.00.17 ± 0.050.5811.2202
B.1.24.20.20 ± 0.100.580.531.7203
B.1.34.10.16 ± 0.060.2580.579.6144
B.1.43.90.16 ± 0.050.540.59.7227
B.1.53.70.23 ± 0.090.12540.570.2163
B.8.14.00.20 ± 0.080.58134.4200
B.8.24.10.17 ± 0.050.2580.586.4143
B.8.34.10.20 ± 0.060.12580.513.3247
B.8.43.70.17 ± 0.060.2580.517.4209
B.8.54.20.19 ± 0.050.0640.543.7162
B.35.16.10.17 ± 0.040.0340.55.4250
B.35.26.60.16 ± 0.050.0320.58.7235
B.35.37.10.16 ± 0.060.0340.57.0232
B.35.43.90.23 ± 0.060.12580.514.7224
B.35.519.60.17 ± 0.050.01520.258.0249
  • a ITZ, itraconazole; FCZ, fluconazole; AmB, amphotericin B.

  • b Data are means ± SD.

  • c Different phenotypes of strains recovered from the brain on day 1 (B.1.X), day 8 (B.8.X), and day 35 (B.35.X) were studied.