TABLE 4.

Comparison of antibody isotypes in responders to RAMA-E among individuals susceptible to and protected against P. falciparum infection during the course of the study

Antibody isotypePrevalenceaAntibody levelb
Protected (n = 25)Susceptible (n = 41)PcProtected (n = 25)Susceptible (n = 41)Pd
IgG19280.490.2960.140 (0.130, 0.465)0.110 (0.030, 0.170)0.0161
IgG23221.950.3960.020 (0.005, 0.045)0.020 (0.000, 0.030)0.4034
IgG38868.290.0830.160 (0.130, 0.295)0.030 (0.010, 0.095)0.0003
IgG41217.070.7300.000 (0.000, 0.010)0.000 (0.000, 0.010)0.7959
IgM6043.900.3100.050 (0.005, 0.240)0.010 (0.000, 0.140)0.1502
  • a Percentage of positive sera defined as those that gave OD values greater than the cutoff OD.

  • b Antibody levels are presented as median OD values (lower quartile, upper quartile).

  • c Antibody prevalences of protected and susceptible groups were compared using Fisher's exact test.

  • d Antibody levels of protected and susceptible groups were compared using the Mann-Whitney test.