TABLE 1.

List of open reading frames of P. gingivalis which were identified by DDRT-PCR as upregulated within GECs

LocusaPutative identificationGeneCellular role(s)
PG0130Phosphoglycerate mutasepgmEnergy metabolism, glycolysis-gluconeogenesis
PG0147b,cHypothetical protein
PG0148cSigma 54-dependent transcriptional regulatorRegulatory functions, DNA interactions
PG0155dRiboflavin biosynthesis protein RibDribDBiosynthesis of cofactors, prosthetic groups, and carriers: riboflavin, FMN, and FAD
PG0156dModification methylase, HemK familyUnknown function, general
PG0159Endopeptidase PepOpepOProtein fate, degradation of proteins, peptides, and glycopeptides
PG0165Heat shock protein 15hslRProtein synthesis, other
PG0212Precorrin-6y c5, 15-methyltransferase, putativeBiosynthesis of cofactors, prosthetic groups, and carriers: heme, porphyrin, and cobalamin
PG0326Hypothetical protein
PG0338Hypothetical protein
PG04818-amino-7-oxononanoate synthasebioF-1Biosynthesis of cofactors, prosthetic groups, and carriers: biotin
PG0525CTP synthasepyrGPurines, pyrimidines, nucleosides, and nucleotides: pyrimidine ribonucleotide biosynthesis
PG0534Hypothetical protein
PG1592HDIG domain proteinEnergy metabolism: electron transport; hypothetical protein: domain
PG1638Thioredoxin family proteinEnergy metabolism, electron transport
PG1642Cation-transporting ATPase, EI-E2 family, authentic frameshiftTransport and binding proteins: cations
PG1683cConserved hypothetical protein
PG1684cHypothetical protein
PG1750Alpha-1,3/4-fucosidase, putativeCell envelope, biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
PG17808-amino-7-oxononanoate synthasebioF-3Biosynthesis of cofactors, prosthetic groups, and carriers: biotin
PG2080Adenosylmethionine-8-amino-7-oxononanoate aminotransferasebioABiosynthesis of cofactors, prosthetic groups, and carriers: biotin
PG2165Glycyl-tRNA synthetaseglySProtein synthesis, tRNA aminoacylation
PG22052-Dehydropantoate 2-reductase, putativeBiosynthesis of cofactors, prosthetic groups, and carriers: pantothenate and coenzyme A
PG2206bABC transporter, ATP-binding proteinTransport and binding proteins, unknown substrate
PG2227Hypothetical protein
  • a TIGR locus designation.

  • b Identified from more than one clone.

  • c Two loci with the consecutive numbers were identified from the same clone. The cloned fragments contained the 5′ end of one and 3′ end of the other.

  • d Two loci were identified from one clone. The cloned fragment contained 5′ ends of the two loci.