TABLE 3.

Effect of sapA on human inoculation with H. ducreyia

Volunteer (gender)No. of days of observationStrainbDose (CFU)cNo. of initial papulesNo. of initial pustulesFinal outcome of site
No. of papulesNo. of pustulesNo. of papules/pustules that resolved
346 (male)6P81333
M42-1653221
347 (male)6P813221
M42-165333
348 (male)7P8131111
M42-165303
349 (female)6P97333
M47-1883112
350 (male)6P973221
M47-188303
351 (female)7P973112
M47-188202
  • a Volunteers 346, 347, and 348 were inoculated in the first iteration; volunteers 349, 350, and 351 were inoculated in the second iteration. See the text for details.

  • b P, parent strain 35000HP; M, mutant strain 35000HPsapA.

  • c 42-165, one dose each of 42, 84, and 165 CFU; 47-188, one dose each of 47, 94, and 188 CFU.