TABLE 1.

Differential expression of genes in the lmr2 locus from microarray expression profiles of bone marrow-derived macrophages from C.B6-(lmr1, lmr2), B6, and Bc mice

Mouse strains comparedGeneaLocation on chromosome 9 (Mb)Normalized expressionb in strain:Expression ratio in strains comparedResponsec
B6C.B6-(lmr1, lmr2)Bc
B6 vs Bc
Casp4 5.313.520.760.536.64U
Mmp13 7.272.890.530.763.80U
Mmp8 7.564.351.461.113.93U
Acp5 21.933.301.061.043.18U
Anln 22.140.072.190.620.11D
Fli1 32.231.020.633.680.28D
Chek1 36.520.241.650.750.32D
Usp2 43.880.680.930.223.05U
H2afx 44.140.120.922.040.13D
Tagln 45.740.270.350.880.31D
Cadm1 47.340.071.120.520.14D
C.B6-(lmr1, lmr2) vs Bc
Mmp12 7.350.242.020.424.78U
Anln 22.130.072.190.623.55U
Fli1 32.231.020.633.680.17D
Usp2 43.880.680.930.224.17U
  • a Genes present within the lmr2 locus (Mb 0 to 50, chromosome 9) and with L. major responses that are more than 3-fold different between strains are listed.

  • b The normalized expression level for each gene is defined as its expression level in infected macrophages divided by that in uninfected macrophages.

  • c D, decreased response in resistant mice [B6 and C.B6-(lmr1, lmr2) mice] relative to the response in Bc mice; U, increased response in resistant mice [B6 and C.B6-(lmr1, lmr2) mice] relative to the response in Bc mice. Fli1 is the only gene in the locus that presents a similar differential response in both B6 and C.B6-(lmr1, lmr2) mice compared to the response in Bc mice.