TABLE 2.

Comparison of the moonlighting actions of the M. tuberculosis Cpn60 proteins

ActivityObservationa
Cpn60.1Cpn60.2
Induction of monocyte cytokine synthesis+++
Induction of whole-blood cytokine synthesis+++
Induction of classic macrophage activation?-
Induction of bone breakdown in vitro--
Inhibition of bone breakdown++-
Inhibition of osteoclast formation++-
Release from bacterium++
% Binding to circulating monocytes8647
Role of TLR2 in monocyte activation-Si
Role of TLR4 in monocyte activation++++
Involvement of Myd88StWk
  • a St, strong; Wk, weak; Si, significant.