TABLE 4.

Synthetic compounds are less effectual than spermine at increasing gonococcal resistance to PMB

CompoundaNet chargeMBC of PMB (μg/ml)ΔMBCb
0 mM compound8 mM compound
Spermine+49.7662564
Propanediamine+29.7639.064
Hexadiamine+29.7678.138
Hexamethylene tetramine09.7619.532
Tris+19.764.880.5
Pyrophosphate−49.7639.064
  • a Chemical names of compounds: spermine, spermine tetrahydrochloride; propanediamine, 1,3-diaminopropane dihydrochloride; hexadiamine, 1,6-diaminohexane; hexamethylene tetramine, 1,3,5,7-tetraazatricyclo-[3.3.1.13,7]decane; Tris, 2-amino-2-hydroxymethyl-1,3-propanediol; pyrophosphate, sodium diphosphate tetrabasic.

  • b Fold change in PMB MBC in the presence versus absence of compound.