TABLE 3.

Virulence determinants tested in only one infection model

Virulence determinantMutant phenotype in selected virulence modelReference
RpoE alternative sigma factorDoes not survive in murine macrophages53
RpoN alternative sigma factorDoes not survive in murine macrophages141
RpoN enhancer binding proteinDecreased virulence in rat agar bead model68
Secreted lipaseDecreased epithelial cell invasion116
KatB catalase/ peroxidaseDecreased survival in murine macrophagesa
SodC superoxide dismutaseDoes not survive in murine macrophages76
Melanin-like pigmentDoes not survive in murine macrophages75
Pbr regulatorDecreased virulence in C. elegans131
AmiI amidaseDecrease (1 log unit) in bacterial burden in rat agar bead infections10
Acyl carrier proteinDecreased virulence in C. elegans152
  • a —, K. E. Keith and M. A. Valvano, unpublished results.