TABLE 2.

Binding of Caf1 peptides to DR molecules

PeptideRelative affinitya of:
DR1DR3DR4DR7DR11DR13DR15
11>1,0005591>1,357>2,7330.1
2125610.4248>2,73364
3539158459700>2,733>208
4545173139326843
510>1,00028036>1,357>2,73380
663080061236849>2,733>208
71,3195740.2414192,000133
82,582>1,0004239>1,357>2,733>208
9>2,563>1,000>1,250>3,365>1,357>2,733>208
10504>1,000153949>2,733111
11121787547830469>208
12>2,563>1,000>1,2501,65641,286119
13>2,563121,600>1,357>2,733>208
14519474535>2,7337
152>238273434>62653
1679>1,00015980>2,733148
  • a Values are expressed as the relative affinity, i.e., the ratio of the IC50 of the test peptide to the IC50 of a reference peptide chosen as a high binder for each allele. High- and intermediate-affinity vales were interpreted as follows: <10, high affinity; <100, intermediate affinity (both types of values are indicated in boldface).