TABLE 1.

Characteristics of factor H-binding protein variants

fHbp IDaSubfamilybVariant groupcModular groupdPercentage among group B disease isolatesefH-binding ratiof
United StatesUnited KingdomFrance
1B1I294201.0
4B1I72470.3
6B1I0000.7
13B1I51020.4
14B1I57230.1
15B1IV0.32260.1
55B1IV0001.6
22A2III0.30.20.42.9
19A2VI138191.9
77A2VI0001.6
28A3II0001.0
175A3IX0000.8
45A3V0.3415.2
79A3V0003.0
67A3VIII0001.8
207A/B1/2VII0001.0
  • a fHbp ID from the fHbp database at http://pubmlst.org/neisseria/fHbp/.

  • b Subfamily as defined by Fletcher et al. (7) and Murphy et al. (18).

  • c Variant group as defined by Masignani et al. (17).

  • d Modular group as described by Beernink and Granoff (3) and Pajon et al. (19).

  • e From population-based surveillance of group B disease in the United States (excluding an epidemic in Oregon), the United Kingdom, and France (18). For fHbp variants not observed in any of the three countries listed, the source isolates came from other countries (18).

  • f Ratio of the respective concentrations of purified fH to obtain an OD405 of 1.0 with fHbp ID 1 compared to that of the test fHbp as measured by ELISA. Ratios above 1 indicate higher binding; ratios below 1 indicate lower binding.