Table 4.

S. Typhimurium genes upregulated at the mucosal walla

COGs classLocus tagGeneFunction or productChange in expression level (fold)P value
Amino acid transport and metabolismSTM3592yhiPPutative peptide transport protein2.080.049
Carbohydrate transport and metabolismSTM0310gmhAPhosphoheptose isomerase2.060.037
STM1558Putative glycosyl hydrolase2.130.017
STM2431ptsHPhosphohistidinoprotein-hexose phosphotransferase2.290.017
STM2433crrGlucose-specific IIA component2.40.036
Cell cycle control, mitosis, and meiosisSTM0132ftsAATP-binding cell division protein2.370.019
STM3371yhdEPutative inhibitor of septum formation2.260.0198
STM3374mreBRod shape-determining protein2.130.014
Cell motilitySTM1177flgEFlagellar hook protein2.640.03
Cell wall/membrane biogenesisSTM0124murFd-Alanine-d-alanine ligase2.090.044
Energy production and conversionSTM4439cybCCytochrome b5622.060.03
Function unknownSTM0119yabBPutative cytoplasmic protein2.280.042
STM1088pipBSecreted effector protein2.350.016
STM3347yhcBPutative periplasmic protein2.420.037
General function prediction onlySTM1581yddEPutative phenazine biosynthetic protein2.020.045
STM2580eraGTPase2.090.028
STM2969ygdHPutative nucleotide binding3.180.012
Inorganic ion transport and metabolismSTM4324cutAPutative periplasmic divalent cation tolerance protein2.30.02
Not in COGsSTM0471ylaCPutative inner membrane protein2.060.003
STM1059ycbWPutative cytoplasmic protein2.710.03
STM1092Putative cytoplasmic protein2.320.024
STM1601ugtLPutative membrane protein2.10.04
STM2983orfXPutative lipoprotein2.090.01
Nucleotide transport and metabolismSTM1163pyrCDihydroorotase2.090.013
Posttranslational modification, protein turnover, and chaperonesSTM1682tpxThiol peroxidase2.790.038
STM3342sspAStringent starvation protein A2.230.041
TranscriptionSTM1704Putative regulatory protein2.730.022
STM3320rpoNSigma 542.090.022
STM3515yciTTranscriptional activator20.026
STM4318Putative acetyltransferase2.1980.019
TranslationSTM3418rpsM30S ribosomal subunit protein S132.730.026
  • a Genes selected as genes of interest showed a >2-fold increase and a P value of <0.05.