Table 5.

S. Typhimurium genes downregulated at the mucosal walla

COGs classLocus tagGene nameFunction or productChange in level of expression (fold)P value
Amino acid transport and metabolismSTM0067carBCarbamoyl-phosphate synthase large subunit; putative ABC transporter2.90.035
STM1255Periplasmic binding protein2.490.044
STM2055pduUPolyhedral body protein2.0970.031
STM1257Putative ABC transporter protein2.030.006
STM3594prlCOligopeptidase A2.090.0496
Carbohydrate transport and metabolismSTM3784Putative phosphotransferase system mannitol/fructose-specific IIA domain2.320.0199
Cell wall/membrane biogenesisSTM2120asmASuppressor of OmpF assembly mutants2.120.049
Energy production and conversionSTM2057pduWPropionate kinase2.10.006
PSLT027ccdAAntidote2.140.045
STM0813ybhPPutative cytoplasmic protein2.090.025
STM2007Tetratricopeptide repeat protein2.330.034
Not in COGsSTM0903Putative chaperone2.790.003
STM2041pduDPropanediol dehydratase medium subunit2.580.04
STM3688Putative cytoplasmic protein2.160.0499
Replication, recombination, and repairSTM4168nfiEndonuclease V2.220.011
TranscriptionSTM3773Putative transcriptional regulator2.070.019
TranslationSTM2665yfiARibosome stabilization factor2.750.01
  • a Genes selected as genes of interest showed a >2-fold change in expression levels and a P value of <0.05.