Table 3.

Efficacy of COPS-protein conjugate vaccines in protecting CD-1 mice from lethal challenge with wild-type S. Enteritidis R11

VaccineIntraperitoneal challenge dose (CFU)aMortality (no. of dead mice/total no. of mice)P valuebVaccine efficacy (%)
PBS (control)5 × 10512/12
Conjugate vaccines
    O:H 1:1 lot 15 × 1050/12<0.001100.0
    O:H 1:1 lot 25 × 1051/12<0.00191.7
    O:H polymer5 × 1052/12<0.00183.3
    O:H 10:15 × 1052/12<0.00183.3
    O:H Amox.5 × 1051/12<0.00191.7
    O:CRM1975 × 1053/12<0.00175.0
PBS1 × 10612/13
Conjugate vaccines
    O:H 1:1 lot 11 × 1061/13<0.00191.7
    O:H 1:1 lot 21 × 1063/13<0.0175.0
    O:H polymer1 × 1062/12<0.00181.9
    O:H 10:11 × 1068/130.1633.3
    O:H Amox.1 × 1062/13<0.00183.3
    O:CRM1971 × 1063/13<0.0175.0
    O:H 1:1 lot 25 × 1060/3
  • a IP LD50 of 2.2×105 CFU.

  • b The mortality rate of the conjugate vaccine group was compared to that of the PBS-immunized control animals by two-tailed Fisher's exact test.