Table 1.

Drug-targeting attributes characterized within the genomes of 22 NIAID category A, B, and C priority microbial pathogensa

OrganismbNo. of proteins withc:
No human homologsHuman homologs
NNSNASNDNDSHHSHAHASHDHDS
BAC2154818345339216239001461
BAR6315819981313983011156
BOR349613706941162115
BRU1723374332421176147011278
BUR29147163555362382910431367
CAM70197271451312283331169
CHL327914546982032116
CLO1074124646130177116711340
COX531422212714165183881182
EHR3175743911492001106
ESC46981269559045277367971402
FRA671792714118170284231226
HEL5615431102910852661151
LIS118353403142216695501313
MYC662564325618144129512314
RIC36809531312391811102
SAL41972264355147264327301391
SHI52074369155941261367731394
STA104286412111514895441240
STR7222127188612034121228
VIB2294405549225222136131321
YER33259658349832249166921340
  • a A selected species was used for each genus. Results for all species within the 22 genera are provided in Fig. S4C in the supplemental material.

  • b BAC, Bacillus anthracis Sterne; BAR, Bartonella henselae Houston-1; BOR, Borrelia burgdorferi B31; BRU, Brucella abortus bv 1 9-941; BUR, Burkholderia mallei ATCC 23344; CAM, Campylobacter jejuni 1336; CHL, Chlamydophila pneumoniae AR39; CLO, Clostridium difficile 630; COX, Coxiella burnetii CbuG Q212; EHR, Ehrlichia canis Jake; ESC, Escherichia coli O157-H7 EC4115; FRA, Francisella tularensis subsp. holarctica 257; HEL, Helicobacter pylori 2017; LIS, Listeria monocytogenes 08-5578; MYC, Mycobacterium tuberculosis H37Rv; RIC, Rickettsia typhi Wilmington; SAL, Salmonella enterica subsp. enterica serovar Typhi Ty2; SHI, Shigella dysenteriae 1012; STA, Staphylococcus aureus subsp aureus MRSA252; STR, Streptococcus pneumoniae 70585; VIB, Vibrio cholerae 121291; YER, Yersinia pestis Angola.

  • c S, significant similarity to a protein with associated 3-D structure in the Protein Data Bank; A, significant similarity to an approved drug target; D, significant similarity to a drug target under experimental testing; N, no significant similarity to a human protein; H, significant similarity to a human protein.