Table 2.

Oral LD50 analysis of attenuated NTS strains

StrainGenotypeLD50 (CFU)
S. Typhimurium I77a
CVD 1920ΔguaBA>7.8 × 108
CVD 1921ΔguaBA ΔclpP>8.0 × 109
CVD 1923ΔguaBA ΔclpP ΔfliD>7.0 × 109
S. Enteritidis R11a
CVD 1940ΔguaBA>1.1 × 109
CVD 1941ΔguaBA ΔclpP>1.3 × 1010
CVD 1943ΔguaBA ΔclpP ΔfliD>9.8 × 109
  • a Oral LD50 of wild-type strains is 2×104 CFU.