Table 4.

Vaccine-induced protection against wild-type S. dysenteriae 1 challenge

Vaccine strainVaccine dose (CFU)Challenge dose (CFU)No. of animals protecteda/total no. of animals
CVD 12551091084/4
CVD 12561091077/7
10910813/13
1091093/4
CVD 12571091088/8
CVD 1255(pOmpC-StxB)1091088/8
CVD 1255(pTrc-StxB)1091086/6
None (PBS) (control)1080/9
  • a Protection against full-blown keratoconjunctivitis (score of 4) at any time point postchallenge.