TABLE 2

Bacterial loads in fluids and tissues in the pneumonia model with P. aeruginosa PAO1

Time and conditionaBacterial load (log10 CFU per g of tissue or per ml of fluid) in:Bacteremia (%)
SpleenLungsBlood
4 h
    N2.64 ± 0.697.77 ± 0.610.26 ± 0.3644.44
    H3.10 ± 0.807.79 ± 0.420.99 ± 0.8461.11
Time of death
    N6.96 ± 0.579.81 ± 0.457.90 ± 0.67100
    H5.27 ± 0.60c9.04 ± 0.58c5.66 ± 0.78b100
    H (6 h) + N6.60 ± 0.349.79 ± 0.276.30 ± 0.46d100
  • a N, normoxia; H, hypoxia.

  • b P < 0.01 (H versus N at the time of death).

  • c P < 0.001 (H versus N at the time of death).

  • d P < 0.05 [H (6 h) + N versus N at the time of death].