TABLE 2.

Toxicities of VirB8 interaction inhibitors against mammalian cellsa

CompoundConcn (μM)% Cytotoxicity
DMSONA0
B8I-15096
2593
12.52
50
B8I-2509
250
12.50
50
B8I-35020
250
12.50
50
B8I-45025
2519
12.511
50
B8I-65017
2510
12.513
514
B8I-750100
25100
12.5100
5100
B8I-85013
2517
12.514
512
B8I-9507
256
12.58
58
B8I-105012
2510
12.514
515
B8I-115053
2536
12.516
513
B8I-12509
258
12.58
56
B8I-1350100
25100
12.5100
527
B8I-14504
250
12.50
50
B8I-155050
2516
12.50
50
B8I-16500
251
12.50
50
B8I-175016
258
12.54
53
B8I-185053
2550
12.548
537
B8I-195042
2545
12.549
50
B8I-205010
2517
12.50
50
  • a Determined using the cytotox96 kit (Promega). The averages of results from parallel experiments in three wells are shown. The DMSO used to dissolve the compounds was not toxic, and values were set to 0%. NA, not applicable.