TABLE 3.

Toxicities of VirB8 interaction inhibitors at concentrations not toxic for mammalian cells against B. abortus 2308

CompoundConcn (μM)Toxicitya
TSBDMEM
DMSONA1.001.00
B8I-112.50.991.00
B8I-212.51.001.01
B8I-312.51.000.84
B8I-351.000.96
B8I-451.000.99
B8I-6250.990.99
B8I-751.000.99
B8I-812.51.000.99
B8I-9501.000.98
B8I-10501.000.99
B8I-1112.50.981.00
B8I-12501.011.00
B8I-1412.51.000.99
B8I-1512.50.991.01
B8I-1612.51.021.04
B8I-1712.51.001.01
B8I-1950.990.98
B8I-2012.50.990.99
  • a B. abortus 2308 was grown in rich medium (TSB) or in DMEM. The ratios of surviving bacteria grown in the presence of VirB8 interaction inhibitors to bacteria grown in their absence are shown (averages of duplicate assays). NA, not applicable.