TABLE 1

Phenotypes identified by PheWAS of F10 rs3211783

PhenotypesConditionPheWAS codeP valueOdds ratioNo. of affected casesTotal no. of casesNo. of controls
Expected (validating) phenotypesOther diseases of blood and blood-forming organs2891.2E−034.65548118,328
Pernicious anemia281.111.3E−026.41219515,680
Hematemesis578.12.5E−025.08215520,426
Abnormality of red blood cells289.93.3E−028.8435118,328
Polycythemia vera, secondary289.81.3E−0410.25318820,349
Unexpected infection-related phenotypesMycoses1177.8E−078.62627821,953
Athlete’s foot110.122.3E−0513.19310621,953
Cellulitis and abscess of trunk681.72.7E−045.60535721,003
Tuberculosis0103.2E−028.9924621,520
Cholangitis575.15.5E−035.24322123,497
Endocarditis420.32.7E−024.98216023,314
Viral infection0793.9E−022.96445921,250
Unexpected liver-related phenotypesPrimary biliary cirrhosis571.62.0E−079.91623219,711
Other disorders of biliary tract575.85.5E−046.05425123,497
Other biliary tract disease5751.6E−033.88658723,497
Jaundice (not of newborn)573.52.0E−035.09431619,711
Liver replaced by transplant573.22.4E−034.92432719,711
Other disorders of liver5732.7E−023.17451019,711
Cirrhosis of liver without mention of alcohol571.512.8E−022.84570919,711
Chronic liver disease and cirrhosis5712.9E−022.4271,14919,711
Malignant neoplasm of liver, primary155.13.9E−024.47217421,458