TABLE 1

Response to inoculation with live H. ducreyi

Volunteer (gender)aObservation period (days)StrainbDose (CFU)cNo. initial papulesFinal outcome (no. observed)
PapulePustuleResolved
402 (F)14P81312
M65–25911
403 (M)7P81211
M65–2593111
404 (F)9P69312
M41–16411
406 (M)6P69321
M41–164211
407 (M)9P6933
M41–1643111
408 (F)8P3533
M7033
409 (M)7P35321
M70211
410 (M)12P35312
M700
  • a Volunteers 402 and 403 were inoculated in the first group. Volunteers 404, 406, and 407 were inoculated in the second group. Volunteers 408, 409, and 410 were inoculated in the third group. F, female; M, male.

  • b P, parent strain 35000HP; M, mutant strain FX548.

  • c 65–259, one dose each of 65, 130, and 259 CFU; 41–164, one dose each of 41, 82, and 164 CFU.