TABLE 6.

T6SS-1 is required for virulence in the Syrian hamster model of infection

StrainT6SS targetedNo. of animals that succumbed/total no. infected witha:
10°101102103
K96243None5/55/55/5ND
Δhcp1 mutantT6SS-10/50/50/50/5
Δhcp1/hcp1+ mutantT6SS-14/55/55/5ND
Δhcp2 mutantT6SS-24/55/55/5ND
Δhcp3 mutantT6SS-35/55/55/5ND
Δhcp4 mutantT6SS-45/55/55/5ND
Δhcp5 mutantT6SS-55/55/55/5ND
Δhcp6 mutantT6SS-64/54/55/5ND
ΔvgrG1-5′ mutantT6SS-11/51/54/5ND
ΔvgrG1-5/vgrG1+ mutantT6SS-12/55/55/5ND
ΔvgrG1-3′ mutantT6SS-10/50/50/5ND
ΔvgrG1-3/vgrG1+ mutantT6SS-13/55/55/5ND
  • a Groups of five female Syrian hamsters were infected i.p. with a range of 10° to 103 CFU for each strain examined. Mortality was recorded daily for 14 days. ND, not determined.