Table 3.

Moonlighting actions of bacterial metabolic proteinsa

BacteriumbMetabolic proteinMoonlighting activityReference(s)
B. stearothermophilusPGISimilar moonlighting actions to human PGI169
X. oryzae pv. oryzaePGIInvolved in virulence177
Chorismate mutaseInvolved in virulence48
B. subtilisPhosphofructokinaseInteractions with RNA processing enzymes41
Glutamate dehydrogenaseTranscription factor binding activity69
N. meningitidisAldolaseAdhesin178
S. pneumoniaeAldolaseAdhesion for atypical cadherin, Flamingo25
GAPDHPlasminogen binding protein24
S. aureusTPIAdhesion to fungal mannans61
GAPDHTransferrin receptor126
S. pyogenesGAPDHFibronectin binding protein137
GAPDHPlasminogen binding protein116
GAPDHCell signaling kinase/ADP ribosylase138, 139
GAPDHNeutrophil evasion protein173
S. oralisGAPDHBinds major fimbriae of Porphyromonas gingivalis130
S. agalactiaeGAPDHImmunomodulator120
EHEC and EPECGAPDHBind plasminogen and fibrinogen52
GAPDHNAD-ribosylating activity2
X. campestrisGAPDHRole in extracellular polysaccharide synthesis117
M. pneumoniaeGAPDHAdhesin for mucin4
β-Subunit of pyruvate dehydrogenaseFibronectin binding protein46
L. plantarumGAPDHBinds mucus and Caco-2 cells103, 148
GAPDHBinds human ABO blood group antigens104
Oral streptococciPhosphoglycerate kinasePlasminogen binding protein102
Phosphoglycerate mutasePlasminogen binding protein102
Group B streptococciPhosphoglycerate kinaseActin binding protein32
L. lactisPyruvate kinaseBinds to yeast mannan95
L. monocytogenesAlcohol acetaldehyde dehydrogenaseBinds to human Hsp60100
M. tuberculosisGlutamate racemaseDNA gyrase162
cAMP phosphodiesteraseControls cell wall permeability145
AconitaseIron-dependent RNA-binding activity16
Superoxide dismutaseAdhesin binding host GAPD150
Malate synthaseLaminin/fibronectin binding protein101
Mycolyl transferasesFibronectin binding proteins156, 188
M. aviumSuperoxide dismutaseAdhesin binding mucus-associated proteins151
  • a For enolase, see Table 2.

  • b L. lactis, Lactococcus lactis.