Table 1.

R. conorii infection induces expression of IFN-regulated genes in HUVECsa

Gene nameGenBank accession no.Gene fold expression
ISG15NM_0051018.7
SOCS1NM_0037458.6
OAS1XM_3712926.4
IL2RANM_0004173.2
GBP1NM_0020532.8
NFkB1NM_0039982
JAK3NM_0002151.9
SMAD3NM_0059021.9
IRF9NM_0060841.8
IRF1NM_0021981.8
CXCL9NM_0024161.8
STAT1NM_0073151.5
JUNBNM_0022291.4
SIT1NM_0144501.4
IFNGR1NM_0004161.3
STAT2NM_0054191.2
IFNAR1NM_0006291.1
JAK2NM_0049721
IFNGNM_000619−1
JAK1NM_002227−1
SOCS2NM_003877−1
PIAS2NM_004671−1
TYK2NM_003331−1.2
PIAS1NM_016166−1.4
STAT4NM_003151−1.7
SOCS3NM_003955−2
  • a HUVECs were infected with R. conorii for 48 h. The quantitative RT-PCR-based arrays were performed to screen a number of specific genes linked to the JAK-STAT pathway. The names of the different genes and their accession numbers are derived from GenBank. The fold induction values were calculated relative to the uninfected control, and a change of 2-fold was considered significant.