Table 1

Known AVGs

Pathogen(s)Gene(s)Process(es) inhibited by presence of functional gene(s)Reference(s)
Shigella/EIECnadA/nadBT3SS secretion41, 42
Shigella/EIECcadAPMN transepithelial migration, ShET1/ShET2 enterotoxin activity, phagolysosome escape9, 18, 32, 33
ShigellaspeGOxidative stress survival4
ShigellaompTStability of IcsA3
SalmonellalacIExpression of SPI-2 genes16
Burkholderia pseudomalleiaraA-araHVirulence in golden Syrian hamster model36
Yersinia pestisrcsA, nghABiofilm formation, biofilm stability14, 15, 49
Yersinia pestislpxLProtection from host immune response35
Francisella tularensis subsp. tularensis and holarcticapepOSystemic spread of pathogen21