Table 2

Distribution of virulence-associated traits and phylogenetic group among 6 groups of extraintestinal E. coli isolates

Trait categorySpecific traitPrevalence of traita,b within group, no. (column %)P valued (across all 6 groups)
Matched setscClassic ExPEC (n = 12)ST131 case reports (n = 5)
ST131, FQ-R (n = 11)ST131, FQ-S (n = 11)Non-ST131, FQ-R (n = 11)Non-ST131, FQ-S (n = 11)
AdhesinpapAHe0 (0)1 (9)3 (27)3 (27)11 (92)0 (0)<0.001
papG allele II1 (9)0 (0)4 (36)1 (9)6 (50)0 (0)0.01
papG allele III0 (0)0 (0)0 (0)1 (9)5 (42)0 (0)0.005
sfa/focDE0 (0)0 (0)1 (9)3 (27)8 (67)0 (0)<0.001
sfaS0 (0)0 (0)0 (0)2 (18)4 (33)0 (0)0.03
iha11 (100)10 (91)6 (55)1 (9)7 (58)5 (100)<0.001
ToxinhlyD1 (9)0 (0)0 (0)3 (27)8 (67)0 (0)<0.001
sat11 (100)9 (82)6 (55)1 (9)4 (33)5 (100)<0.001
vat0 (0)0 (0)3 (27)5 (46)7 (58)0 (0)0.001
SiderophoreiroN0 (0)1 (9)1 (9)5 (46)8 (67)0 (0)<0.001
fyuA11 (100)11 (100)8 (73)8 (73)12 (100)5 (100)0.03
ireA0 (0)0 (0)0 (0)2 (18)4 (33)0 (0)0.03
iutA11 (100)10 (91)8 (73)4 (36)6 (50)5 (100)0.002
CapsuleK10 (0)0 (0)1 (9)4 (36)5 (42)0 (0)0.009
Misc.fusp11 (100)11 (100)4 (36)5 (46)9 (75)5 (100)<0.001
ibeA0 (0)6 (55)2 (18)2 (18)3 (25)0 (0)0.04
H7 fliC0 (0)0 (0)0 (0)2 (18)4 (33)0 (0)0.03
malX11 (100)10 (91)5 (46)4 (36)9 (75)5 (100)0.001
clbB/N0 (0)0 (0)2 (18)4 (36)7 (58)0 (0)0.001
Phylo. gp.gB211 (100)11 (100)3 (27)4 (36)8 (67)5 (100)<0.001
D0 (0)0 (0)7 (64)2 (18)4 (33)0 (0)0.001
  • a Traits shown are those that yielded a P value of <0.05 (by Fisher's exact test) in the 6-group comparisons. papAH (P fimbria structural subunit), papG alleles II and III (P adhesin variants), sfa/focDE (S and F1C fimbriae), sfaS (S fimbriae), iha (adhesin-siderophore), hlyD (alpha hemolysin), sat (secreted autotransporter toxin), vat (vacuolating toxin), iroN (catecholate siderophore receptor), fyuA (yersiniabactin receptor), ireA (siderophore), iutA (aerobactin receptor), K1 (group 2 capsule variant), ibeA (invasion of brain endothelium), usp (uropathogenic-specific protein), H7 fliC (flagellar variant), malX (pathogenicity island marker), clbB/N (polyketide synthesis).

  • b Traits detected in ≥1 isolate but not yielding a P value of <0.05: papG allele I (P adhesin variant), focG (F1C fimbriae), afa/draBC (Dr-binding adhesins), fimH (type 1 fimbria adhesin), hra (heat-resistant agglutinin), hlyF (variant hemolysin), cnf1 (cytotoxic-necrotizing factor 1), pic (secreted autotransporter), tsh (temperature-sensitive hemagglutinin), kpsM II (group 2 capsules), K5 (group 2 capsule variant), K15 (group 2 capsule variant).

  • c Sets were matched for collection, year of isolation, and locale.

  • d P values are by Fisher's exact test (two-tailed).

  • e papC, papEG, and papG (P fimbria assembly, tip pilins, and adhesin) yielded results similar to those for papAH.

  • f Misc., miscellaneous traits.

  • g Phylo. gp., E. coli phylogenetic group (A, B1, B2, D).