Table 4

Association of virulence-associated genes with mouse sepsis model outcomes among 61 extraintestinal E. coli isolates

TraitaNo. of isolates with trait (% of 61)Percent lethality, median (range)bP valuecMean status, median (range)bP valuec
Trait absentTrait presentTrait absentTrait present
papAH18 (30)30 (0–100)95 (0–100)0.062.0 (1.0–5.0)4.7 (1.3–5.0)0.007
papG III6 (10)40 (0–100)48 (0–100)0.052.7 (1.0–5.0)5.0 (1.3–5.0)0.01
vat15 (25)26 (0–100)100 (0–100)0.022.2 (1.0–5.0)4.7 (1.3–5.0)0.03
kpsM II45 (74)0 (0–100)70 (0–100)0.0081.6 (1.0–5.0)3.7 (1.3–5.0)0.008
K110 (16)30 (0–100)100 (0–100)0.032.3 (1.0–5.0)4.3 (1.0–5.0)0.05
ibeA13 (21)26 (0–100)100 (0–100)0.0052.4 (1.0–5.0)4.2 (1.3–5.0)0.06
clbB/N13 (21)35 (0–100)100 (0–100)0.212.5 (1.0–5.0)4.7 (1.3–5.0)0.048
ExPEC58 (95)0 (0–0)45 (0–100)0.021.3 (1.0–1.7)3.0 (1.0–5.0)0.02
  • a Traits shown are those that yielded a P value of <0.05 for one or both endpoints. clbB/N, polyketide (colibactin) synthesis; ExPEC, extraintestinal pathogenic E. coli (defined as ≥2 of papAH and/or papC [P fimbria structural subunit and assembly], sfa/foc [S and F1C fimbriae], afa/draBC [Dr-binding adhesins], kpsM II [group 2 capsule synthesis], and iutA [aerobactin operon]); ibeA, invasion of brain endothelium; K1, kpsM II variant (K1 capsule); papG III, variant P fimbria adhesin; vat, vacuolating toxin.

  • b Outcomes were the percent mouse lethality and mean mouse status (over 3 days) among all mice challenged with a particular strain (median, n = 5 mice per strain; range, 5 to 39 mice).

  • c P values were calculated using the Mann-Whitney U test (two-tailed).