Table 1

Examples of bacterial heme and iron uptake systems

System typeExampleRepresentative organism(s) (reference)
Ferrous iron uptakeFeoV. cholerae (51), E. coli (52), Shigella flexneri (141), S. enterica serovar Typhimurium (55)
MtsStreptococcus pyogenes (142)
Ferric iron receptorFecAE. coli (143), S. flexneri (144)
Siderophore systemYbtY. pestis (46)
FhuHaemophilus influenzae (145), Streptococcus agalactiae (146)
SnfaS. aureus (147)
MbtM. tuberculosis (148)
VibV. cholerae (149)
EntE. coli (150), Shigella dysenteriae (151), S. enterica serovar Typhimurium (152)
Transferrin receptorTbpN. meningitidis (48), H. influenzae (153)
TpnS. aureus (154)
Lactoferrin receptorLbpNeisseria gonorrhoeae (155)
UnnamedH. influenzae (156)
Heme receptorHutABartonella quintana (157), V. cholerae (158)
HxuCH. influenzae (159)
ShrS. pyogenes (65)
ChuAE. coli (160)
ShuAS. dysenteriae (161)
Hemoglobin receptorIsdBS. aureus (44)
HmbRN. meningitidis (162)
Haptoglobin receptorHarAS. aureus (163)
HhuAH. influenzae (164)
HpuABN. meningitidis (165)
Hemophore systemIsdX1X2B. anthracis (74)
Rv0203M. tuberculosis (166)
HasASerratia marcescens (167)
Hemoglobin proteaseHbpE. coli EB1 (08-K43) (168)
Ferritin receptorIlsAB. cereus (61)