Table 1

M. avium subsp. paratuberculosis proteins implicated in invasion

Locus tagProteinHost cell typeEvidenceReference
MAP_2121cMajor membrane protein IMDBKAntibody against protein blocks invasion51
MAP_3464NADH-dependent oxidoreductaseMDBKGene knockout lowers invasion, and complementation restores invasion23
MAP_3212NADH-ubiquinone oxidoreductaseMDBKGene knockout lowers invasion23
MAP_3607Mycobacterial cell entry (Mce1D)MDBKGene knockout lowers invasion23
MAP_0941Arginine deaminase (ArcA)MDBKGene knockout lowers invasion23
MAP_2808Potassium transporter (TrkA)MDBKGene knockout lowers invasion23
MAP_2938cIsoprenoid biosynthesisCalf intestineGene knockout lowers invasion28
MAP_1242Lipotripeptide biosynthesis (PstA)Calf intestineGene knockout lowers invasion55
MAP_0482Transcriptional regulator (LuxR)MDBKGene overexpression increases invasion38
MAP_3985cHypothetical proteinMDBKSecreted protein. Binds Cdc42 and activates it23