Table 3

Serum levels of liver enzymes after tunicamycin treatmenta

Mouse groupALT (U/liter)AST (U/liter)
VehicleTunicamycinVehicleTunicamycin
WT63.6 ± 50.850.1 ± 26.731.8 ± 4.585.4 ± 16.6
STAT3hepΔ49.5 ± 16.039.8 ± 5.742.4 ± 7.6154.7 ± 58.0
  • a STAT3hepΔ mice and control littermates received i.p. injections of tunicamycin, and serum was collected after 24 h. ALT and AST concentrations were measured in a kinetic spectophotometry assay. Values are means ± standard deviations (results from one experiment; n = 4 to 6 mice/group).