TABLE 2

Levels of BAL specimen cytokines and chemokines (pg/ml) 7 days postinfectiona

CytokinefMean concn for the group (± SE [pg/ml])aFold change in:
WT controlSP-D−/− controlWT infectedSP-D−/− infectedWT miceSP-D−/− mice
IFN-γ9.2 (0.1)12 (2)50 (10)b49 (8)b6.0e4.2
TNF-α10.1 (0.5)10.1 (0.5)20 (3)b16 (2)b,c2.01.6
IL-416.2 (0.3)16.1 (0.3)110 (20)b160 (20)b7.09.8
IL-59.3 (0.07)9.3 (0.07)310 (40)b550 (70)b,c33.8e59.2
IL-614 (1)14 (1)130 (20)b200 (30)b9.413.9
IL-129 (2)40 (8)d60 (8)b81 (7)b6.7e2.0
IL-1317 (2)17 (2)800 (80)b800 (200)b47.1e49.1
IL-175 (1)5 (1)7.4 (0.6)9 (1)b1.41.6
IP-108 (2)7 (2)57 (6)b140 (10)b,c7.3e18.8
MCP-119 (2)24 (5)300 (30)b530 (50)b,c16.022.2
MIG5 (2)7 (3)29 (6)42 (9)b5.56.4
MIP-1α27 (8)29 (7)120 (20)190 (40)b4.66.7
VEGF90 (10)160 (10)d30 (8)b50 (20)b0.40.3
FGF basic40 (9)90 (20)100 (20)170 (30)2.51.9
KC180 (60)230 (50)94 (5)130 (40)0.60.6
  • a Data are from 10 to 15 mice/group and from three to four independent experiments.

  • b Values for infected mice are significantly different than for the respective saline-treated control mice.

  • c Values for infected SP-D−/− mice are significantly different than for infected WT mice.

  • d Baseline values for SP-D−/− mice are significantly different than for WT mice.

  • e Fold change is significantly different in WT versus SP-D−/− mice.

  • f VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor.