TABLE 3

Histological analysis of H&E-stained lung sections at 7 days postinfection

GenotypeMean histological scorea
NecrosisHemorrhageEdemaCryptococcusInflammationComposite
WT2.31.30.84.34.012.8
SP-D−/−1.41.00.03.62.68.6
IL-5Tg3.32.31.66.55.819.4
IL-5TgxSP-D−/−1.71.00.73.03.09.3
  • a Data are for 2 to 5 mice/group. All sham-infected mice received a score of 0 for each category except IL-5Tg mice, which received a mean score of 0.3 for inflammation, and IL-5TgxSP-D−/− mice, which received a mean score of 0.5 for hemorrhage and 1 for inflammation.