TABLE 2

Genotypic association of NOS2 SNPs to asymptomatic malariaa

SNP no.SNP referencePosition (Mb)Gene regionbAllelescMinor allele frequencyGenotypesAsymptomatic carriers (n = 378)Noncarriers (n = 790)PadjOR (95% CI)Pcorr
1rs1165371626084532Intron 26G/C0.274CC/GC/GG190/156/24407/318/530.78560.97 (0.58–1.63)NSd
2rs379475626086629Intron 25T/C0.047CC/TC/TT304/34/0653/57/40.53891.14 (0.75–1.74)NS
3rs372972726087316Intron 24A/G0.172GG/AG/AA272/90/15531/233/240.27510.88 (0.70–1.11)NS
4rs372950726088432Intron 22C/G0.079GG/CG/CC308/66/2681/96/90.06741.34 (0.98–1.81)NS
5rs287275326095562Intron 17G/A0.460AA/GA/GG102/201/75219/418/530.76381.03 (0.86–1.23)NS
6rs928280126096473Intron 16*T/G0.248GG/TG/TT235/116/27430/309/500.07840.83 (0.68–1.02)NS
7rs372972026099324Intron 14*T/C0.038CC/TC/TT357/19/1723/66/10.05680.63 (0.38–1.03)NS
8rs1696654526104622Intron 11A/T0.165TT/AT/AA273/92/12535/233/170.31730.89 (0.70–1.13)NS
9rs479506726106675Intron 9G/A0.195AA/GA/GG261/102/15505/245/390.10820.84 (0.67–1.04)NS
10rs372950826109030Intron 7*A/G0.230GG/AG/AA191/152/25489/253/367.90E–041.42 (1.16–1.75)1.66E–02
11rs373001726109102Exon 7T/C0.210CC/TC/TT242/123/12481/274/350.20540.87 (0.70–1.08)NS
12rs650546926111886Intron 5T/A0.231AA/TA/TT189/152/27490/259/331.90E-041.48 (1.21–1.82)3.99E–03
13rs1696656326115949Exon 4C/T0.214TT/CT/CC240/124/14483/263/420.28490.89 (0.72–1.10)NS
14rs379476626121921Intron 2T/C0.173CC/TC/TT275/81/15524/228/300.05690.80 (0.63–1.01)NS
15rs379476726124605Intron 2T/C0.211CC/TC/TT198/146/23515/231/308.00E–051.53 (1.24–1.88)1.68E–03
16rs373001326125918Intron 1*T/C0.247CC/TC/TT211/151/16434/311/400.74630.97 (0.78–1.19)NS
17rs650548326126345Intron 1A/G0.229GG/AG/AA217/139/20473/273/400.47771.08 (0.88–1.33)NS
18rs928279926128728PromoterT/C0.047CC/TC/TT333/38/1712/68/00.28771.25 (0.83–1.88)NS
19rs2899879026129014PromoterA/G0.066GG/AG/AA327/46/2684/98/30.92661.02 (0.72–1.44)NS
20rs807834026129212PromoterA/G0.279GG/AG/AA213/130/28390/317/684.18E–020.82 (0.67–0.99)NS
21rs1108035826130596PromoterA/G0.250GG/AG/AA226/128/17421/309/531.51E–020.77 (0.63–0.95)NS
  • a Association tests were performed using the log-additive model, and the results were adjusted for age and gender (Padj). Significant adjusted P values (Padj < 0.05) and significant Bonferroni-corrected P value (Pcorr < 0.05) are highlighted in boldface.

  • b *, rs9282801 is located in intron 16 in a boundary region to exon 16 (at 88 bp), rs3729720 is located in intron 14 in a boundary region to exon 14 (at 10 bp), rs3729508 is located in intron 7 in a boundary region to exon 7 (at 11 bp), and rs3730013 is located in intron 1 in a boundary region to exon 2 (at 10 bp).

  • c Minor/major frequency alleles are indicated in this column.

  • d NS, not significant.