TABLE 6

Association of NOS2 SNPs with cerebral malariaa

SNP no.SNP referenceGene regionAllelesbMinor allele frequencyGenotypesGenotype no.CM vs UM
CM (n = 127)UM (n = 142)PadjOR (95% CI)
1rs11653716Intron 26G/C0.328CC/GC-GG66/6059/820.075330.64 (0.39–1.05)
2rs3794756Intron 25T/C0.086CC/TC-TT106/20121/210.923231.03 (0.53–2.03)
3rs3729727Intron 24A/G0.214GG/AG-AA77/5087/550.863571.04 (0.63–1.72)
4rs3729507Intron 22C/G0.089GG/CG-CC105/22121/210.703111.14 (0.59–2.2)
5rs2872753Intron 17G/A0.44AA/GA-GG45/8138/1040.121580.66 (0.39–1.12)
6rs9282801Intron 16*T/G0.271GG/TG-TT60/6679/630.151441.43 (0.88–2.34)
7rs3729720Intron 14*T/C0.056CC/TC-TT109/18131/110.065812.09 (0.94–4.66)
8rs16966545Intron 11A/T0.174TT/AT-AA81/4599/420.257471.35 (0.8–2.28)
9rs4795067Intron 9G/A0.155AA/GA-GG87/39107/340.262191.36 (0.79–2.35)
10rs3729508Intron 7*A/G0.188GG/AG-AA91/3685/560.055030.61 (0.36–1.01)
11rs3730017Exon 7T/C0.24CC/TC-TT83/4472/701.89E–020.56 (0.34–0.91)
12rs6505469Intron 5T/A0.167AA/TA-TT96/3191/514.33E–020.58 (0.34–0.99)
13rs16966563Exon 4C/T0.236TT/CT-CC88/3969/737.90E–040.43 (0.26–0.71)
14rs3794766Intron 2T/C0.153CC/TC-TT86/38109/320.189411.45 (0.83–2.52)
15rs3794767Intron 2T/C0.167CC/TC-TT92/3290/490.114350.65 (0.38–1.11)
16rs3730013Intron 1*T/C0.262CC/TC-TT66/6179/630.658621.12 (0.69–1.81)
17rs6505483Intron 1A/G0.199GG/AG-AA79/4890/500.556851.17 (0.7–1.95)
18rs9282799PromoterT/C0.034CC/TC-TTNA/NANA/NANANA
20rs8078340PromoterA/G0.269GG/AG-AA70/5570/690.447260.83 (0.51–1.35)
21rs11080358PromoterA/G0.225GG/AG-AA79/4782/590.529270.85 (0.52–1.4)
  • a Association tests were performed using the dominant model, and the results were adjusted for age and gender (Padj). Significant adjusted P values (Padj < 0.05) are highlighted in boldface. rs16966563 (SNP 13) is still significant after Bonferroni correction (P = 1.58E–02). Introns denoted by asterisks are discussed in Table 2, footnote b. NA, not available.

  • b Indicated as minor/major frequency alleles.