TABLE 3

Changes in cytokine and chemokine levels in serum of mice infected with WT CO92 and the Δlpp Δpla double mutant

Day (route of administration) and strainConcna (pg/ml)
TNF-αIFN-γG-CSFGM-CSFM-CSFIL-1αIL-1βIL-2IL-3IL-4IL-5IL-6IL-7IL-9IL-10IL-12(p40) 12(p40)IL-12 (p70)IL-13IL-15IL-17IP-10EotaxinKCLIFLIXMCP-1MIGMIP-1αMIP-2RANTESVEGF
Day 4 (s.c.)
    WT (pg/ml)310 ± 5072,260 ± 4,33010,918 ± 5,975248 ± 15962 ± 38321 ± 113103 ± 2321 ± 25307 ± 48090 ± 173ND3,858 ± 3,58733 ± 4046 ± 10477 ± 67ND62 ± 891,190 ± 1,837124 ± 204230 ± 5161,740 ± 8281,469 ± 1,0203,528 ± 5,06970 ± 1237,822 ± 2,8193,411 ± 4,6277,403 ± 3,517515 ± 276874 ± 1,27278 ± 5711 ± 7
    Δlpp Δpla mutantNDND1,708 ± 987***ND20 ± 20279 ± 17923 ± 26*9 ± 5ND11 ± 29 ± 20309 ± 248**NDND22 ± 22NDNDNDNDND348 ± 97***1,070 ± 199213 ± 114ND8,111 ± 4,454102 ± 39*798 ± 363271 ± 79201 ± 12822 ± 6***5 ± 1
Day 2 (i.n.)
    WT (pg/ml)69 ± 45274 ± 21726,495 ± 12,979274 ± 7989 ± 51876 ± 177148 ± 9811 ± 728 ± 71 ± 356 ± 437,458 ± 3,64323 ± 71,054 ± 165139 ± 7824 ± 10290 ± 166265 ± 10077 ± 22376 ± 3661,654 ± 7422,024 ± 4135,588 ± 4,28298 ± 4615,891 ± 5082,323 ± 2,37652,532 ± 10,237316 ± 122385 ± 10981 ± 4033 ± 34
    Δlpp Δpla mutant37 ± 12*380 ± 41714,299 ± 8,604185 ± 7147 ± 9808 ± 18454 ± 414 ± 416 ± 12ND19 ± 135,465 ± 4,31514 ± 51,054 ± 15362 ± 27*25 ± 18213 ± 144240 ± 11255 ± 34101 ± 116***1,643 ± 4291,289 ± 342***814 ± 401***42 ± 408,389 ± 2,10094 ± 388,079 ± 4,499316 ± 232262 ± 4227 ± 1016 ± 7
  • a Abbreviations and symbols: GM-CSF, granulocyte-macrophage colony-stimulating factor; M-CSF, macrophage colony-stimulating factor; LIF, leukemia inhibitory factor; LIX, lipopolysaccharide-induced CXC chemokine; MIG, monokine induced by gamma interferon; MIP-1α, macrophage inflammatory protein 1α; VEGF, vascular endothelial growth factor; ND, not detected; *, P < 0.05; **, P < 0.01; ***, P < 0.001.