TABLE 3

Microdomain variants resulting in inconsistent loss of antibody bindinga

Peptide namebPeptide sequencecBoLA-DRβ3 haplotyping
SM.E6F7 Md-1GNGTGSSGSN
VP.E6F7-1.2GNGTGSSGSNH(*0601, *1001)(*0902, *1101)
VP.E6F7-1.4GKGTGTSG-NH
SM.StM2 Md-1KGKEGSNGTKK
VP.StM2-1.3KGKTTSGSDGNTKK(*0601, *1001)(*0101, *2703)(*0902, *1101)
SM.StM1 Md-2VNATSGSTNNG
VP.StM1-2.13VN--SGTTGST-NGN(*0103, *0101)(*0601, *1001)(*0902, *1101)
  • a Variant peptides that resulted in a statistically significant decrease in antibody recognition in a minimum of one but not in all biological replicates.

  • b Boldface indicates the parent St. Maries strain homologous peptide; VP indicates the specific variant peptide as defined in Fig. 2 and 3.

  • c Italics indicate insertions relative to the parent St. Maries sequence, dashes indicate deletions, and underlining indicates substitutions.