TABLE 2

Differentially abundant proteins identified in comparative proteomic analysisa

Gene group and GI no.Gene symbolProtein descriptionAvg log2 ratioP valueb
Genes abundant during acute-phase cholera
    38455402LCN2Neutrophil gelatinase-associated lipocalin2.190.0038
    47419918WARSTryptophanyl-tRNA synthetase, cytoplasmic2.180.0046
    4758146DEFA1Neutrophil defensin 11.930.0017
    21614544S100A8Protein S100-A81.820.0037
    24041029NOS2Nitric oxide synthase, inducible1.510.0132
    4557759MPOMyeloperoxidase1.450.0152
    110611220RRBP1Ribosome-binding protein 11.320.0219
    4506773S100A9Protein S100-A91.300.0295
    32313593OLFM4Olfactomedin-41.300.0241
    207452735EPPK1Epiplakin1.260.0377
    19920317CKAP4Cytoskeleton-associated protein 41.060.0328
    47458820STAT3Signal transducer and activator of transcription 31.040.0327
Genes abundant during convalescent-phase cholera
    158937236NPEPPSPuromycin-sensitive aminopeptidase−1.020.0482
    32130518APOC2Apolipoprotein C-II−1.070.0198
    209862837EPHX1Epoxide hydrolase 1−1.110.0010
    22091454GSTA1Glutathione S-transferase A1−1.140.0022
    4502693CD9CD9 antigen−1.240.0059
    4505621PEBP1Phosphatidylethanolamine-binding protein 1−1.280.0414
    4506147PRSS2Trypsin-2−1.310.0021
    4557809OATOrnithine aminotransferase, mitochondrial−1.420.0389
    221316699MGAMMaltase-glucoamylase, intestinal−1.460.0400
    31542986ITLN1Intelectin-1−1.620.0258
    4501901ACY1Aminoacylase-1−1.630.0058
    4557735MAOAAmine oxidase−1.800.0558
    157364974SISucrase-isomaltase, intestinal−1.820.0117
    281485550FBN1Fibrillin-1−2.040.0580
  • a A cutoff of a log2 ratio of >1.0 and <−1.0 was used with a cutoff P value of <0.05.

  • b P values were generated by Student's t test.