TABLE 3

Predicted biological processes, according to Gene Ontology annotation, for differentially abundant proteins recovered from biopsy specimens taken during acute-phase cholera and convalescence

Biological processGO annotation number(s)aProtein(s) in data set
Innate immune response and host interactionsGO:0045087, GO:0002227, GO:0052572, GO:0051701, GO:0044130, GO:0019048, GO:0050777DEFA1, S100A8, S100A9, NOS2, MPO, OLFM4
Defense response to infectious agents (e.g., bacteria and viruses)GO:0042742, GO:0009615, GO:0050832, GO:0031640, GO:0050829, GO:0051712, GO:0002679, GO:0006952, GO:0001878, GO:0001912, GO:0002149, GO:0009267DEFA1, S100A8, S100A9, NOS2, MPO
Cytokine production and regulationGO:0001816, GO:0001817, GO:0032680, GO:0071347, GO:0071356, GO:0032602, GO:0071346, GO:0001960, GO:0030514, GO:0035582S100A8, S100A9, NOS2, FBN1
NF-κB regulationGO:0043123, GO:0051092, GO:0043124S100A8, S100A9, OLFM4
Ion transport and regulation (e.g., iron and calcium)GO:0006826, GO:0033214, GO:0006811, GO:0015891, GO:0032119, GO:0010043, GO:0055074, GO:0051592, GO:0010524, GO:0051480, GO:0048554, GO:0006874, GO:0006816LCN2, S100A8, S100A9
Response to lipopolysaccharideGO:0031665, GO:0071222, GO:0032496LCN2, S100A8, S100A9, NOS2
Regulation of endocytosis and phagocytosisGO:0090382, GO:0048261, GO:0070836, GO:0050764NOS2, APOC2, OLFM4
Posttranslational modificationGO:0071902, GO:0033138, GO:0018119, GO:0031397, GO:0042524, GO:0033137, GO:0001934NOS2, ITLN1
Gene expression and regulationGO:0006351, GO:0010628, GO:0010467, GO:0010629, GO:0000398, GO:0008380, GO:0000122, GO:0006355NOS2, STAT3, CKAP4
ApoptosisGO:0006915, GO:0042981, GO:0006919, GO:2001244, GO:0043066, GO:0097190, GO:2001238LCN2, S100A8, S100A9, MPO, OLFM4
Response to oxidative/cellular stressGO:0070301, GO:0001666, GO:0006801, GO:0006979, GO:0019430, GO:0042744, GO:0071455, GO:0009414, GO:0006749LCN2, NOS2, MPO, CD9, GSTA1
Cellular organizationGO:0031346, GO:0051493, GO:0006914, GO:0016050, GO:0030198, GO:0022617, GO:0030198, GO:0031532, GO:0005856LCN2, S100A8, S100A9, FBN1, EPPK1
Response to drugs/toxinsGO:0042493, GO:0009635, GO:0009636, GO:0045471, GO:0019439, GO:0014070, GO:0042178, GO:0006805LCN2, APOC2, EPHX1, S100A8, S100A9, MAOA, GSTA1
Protein translation, folding, and transportGO:0070207, GO:0006412, GO:0006436, GO:0006418, GO:0051260, GO:0051289, GO:0034214, GO:0015031LCN2, WARS, OAT, RRBP1, OLFM4
Cellular proliferation/differentiationGO:0008285, GO:0030307, GO:0042127, GO:0030154, GO:0001523, GO:0090090, GO:0030857, GO:2000286, GO:0090263, GO:0051899, GO:0008285, GO:0030307, GO:0030855WARS, S100A8, S100A9, NOS2, APOC2, CD9, GSTA1
Blood coagulation and vessel formation/dilationGO:0045765, GO:0001525, GO:0045909, GO:0045907, GO:0045776, GO:0007596, GO:0001570, GO:0002931, GO:0006940, GO:0042310, GO:0001937, GO:0030193, GO:0002576, GO:0030168WARS, NOS2, CD9
Leukocyte chemotaxis and extravasationGO:0006935, GO:0002523, GO:0070488, GO:0030593, GO:0030595, GO:0050900, GO:2000389DEFA1, S100A8, S100A9, OLFM4
Inflammatory responseGO:0002526, GO:0050729, GO:0006954, GO:0002544, GO:0050729S100A8, S100A9, NOS2
Protein metabolism/catabolismGO:0042177, GO:0006527, GO:0006749, GO:0000096, GO:0052547, GO:0030574, GO:0006508, GO:0008652, GO:0055129, GO:0030574, GO:0006576, GO:0010466NOS2, OAT, ACY1, MAOA, NPEPPS, PEBP1
G protein activationGO:0031284, GO:0072584NOS2
Nitric oxide biosynthesis and regulationGO:0007263, GO:0006809, GO:0051001, GO:0046209, GO:0045019, GO:0050999NOS2
Cellular metabolism/catabolismGO:0043457, GO:0044237, GO:0008152, GO:0055114, GO:0034641, GO:0009056NOS2, MPO, OAT, OLFM4, GSTA1
Cholesterol metabolism, modification, and transportGO:0034374, GO:0034372, GO:0034370, GO:0010916, GO:0010902, GO:0051006, GO:0034384, GO:0042953, GO:0042157, GO:0032375, GO:0033344, GO:0043691, GO:0042632, GO:0030301, GO:0034371, GO:0034382MPO, APOC2
Lipid biosynthesis and metabolismGO:0045833, GO:007032, GO:0045723, GO:0010898, GO:0033700, GO:0016042, GO:0060697, GO:0010518, GO:0006641, GO:0019217, GO:0019915APOC2
Small-molecule metabolismGO:0044281APOC2, OAT, MGAM, MAOA, SI, GSTA1
Cell adhesionGO:0007155, GO:0045785CD9, OLFM4
Starch metabolismGO:0005983, GO:0044245, GO:0005975, GO:0046326, GO:0044245MGAM, ITLN1, SI
Signal transductionGO:0007165S100A9, STAT3
Cell-cell signalingGO:0007267, GO:0045113S100A9
Cell spreading and migrationGO:1900026OLFM4