TABLE 1

Occurrence of ECM according to host-parasite strain context

P. berghei strainPresence of PbHMGB2 proteinOccurrence of ECMa
C57BL/6 miceBALB/c mice
WT P. berghei ANKA†, 100% ECMNo ECM, 100% death by hyperparasitemia
+ND†, 65% ECM
KO P. berghei ANKA65% ECM survivalNo ECM, 100% death by hyperparasitemia
+†, 65% ECM
WT P. berghei NK65No ECM, 100% death by hyperparasitemiaND
+No ECM, 100% death by hyperparasitemiaND
KO P. berghei NK65No ECM, no death by hyperparasitemia, 100% survivalND
+NDND
  • a †, death of mice; ND, not determined.