TABLE 1

Response to inoculation of live H. ducreyi strains

Volunteer (gender)aObservation period (no. of days)StrainbDose(s) (CFU)cNo. of initial papulesFinal outcome of papules
No. of pustulesNo. of papules that resolved
454 (F)7P82202
M52–207202
455 (M)9P82312
M52–207312
456 (F)5P82303
M52–207202
457 (F)7P150330
M87–348312
458 (F)5P150202
M87–348101
459 (M)8P77312
M137312
460 (F)12P77330
M137303
  • a Volunteers 454, 455, and 456 were inoculated in the first iteration. Volunteers 457 and 458 were inoculated in the second iteration. Volunteers 459 and 460 were inoculated in the third iteration. F, female; M, male.

  • b P, parent strain 35000HP; M, mutant strain 35000HPΔdksA.

  • c Doses (single doses) inoculated at three sites. 52–207, one dose each of 52, 104, and 207 CFU; 87–348, one dose each of 87, 174, and 348 CFU.