Table 1.

Effects of different C. trachomatis MoPn inocula on pregnancy outcome

Inoculum dose/mouseNo. of pregnant mice that deliveredMean no. of babies born/pregnant mouse ± 1 SDMean no. of gestation days at time of deliveryCharacteristic of conceptus at birtha
Prematurely/total (%)At term/total (%)PrematureNormalMean wt (g) ± 1 SDMean length (cm) ± 1 SD
C. trachomatis MoPn
 107IFU7/7 (100)b 0/7 (0)b  NAc 16.4NA NAMd NAM
 106IFU4/4 (100)b 0/4 (0)b NA16.3NANAMNAM
 105IFU12/13 (92.3)b 1/13 (7.7)b 5f 15.819.01.43 ± 0.082.70 ± 0.07
 104IFU0/7 (0)6/7 (85.7)e 4.1 ± 2.4NA19.61.48 ± 0.192.82 ± 0.12
 103IFU0/4 (0)4/4 (100)6.3 ± 1.7NA19.51.44 ± 0.172.75 ± 0.11
 101IFU0/3 (0)3/3 (100)5.3 ± 1.2NA19.61.62 ± 0.162.87 ± 0.15
105 HK C. trachomatisMoPn0/6 (0)6/6 (100)6.3 ± 1.9NA19.31.33 ± 0.232.65 ± 0.16
HeLa cell extract0/22 (0)22/22 (100)5.3 ± 1.3NA19.31.55 ± 0.212.80 ± 0.25
SPG0/9 (0)9/9 (100)5.4 ± 1.5NA19.31.39 ± 0.192.76 ± 0.18
  • a Body length and weight were measured within 24 h after birth.

  • b P < 0.05 by Fisher’s exact test compared with the HeLa cells extract or HK C. trachomatisMoPn-inoculated group.

  • c NA, not applicable.

  • d NAM, not available for measurement.

  • e One mouse died before delivery.

  • f Babies delivered from one mother.