Table 3.

Cytokine profiles in mice

Time point and exptl groupConcn (pg/ml) of cytokinea
IFN-γTNF-αIL-12IL-10TGF-β1
2 wk
 C57BL/6J35 ± 1056.4 ± 4.2166 ± 2.2150 ± 0.48.5 ± 0.8
 β2−/−46 ± 7  (P = 0.300)b65.9 ± 4.4  (P = 0.828)209 ± 27  (P = 0.248)266 ± 90  (P = 0.326)10.0 ± 0.4  (P = 0.239)
4 wk
 C57BL/6J45 ± 0.263.1 ± 5.584 ± 42131 ± 2110.9 ± 2.2
 β2−/−39 ± 1.5  (P = 0.426)82.4 ± 4.8  (P = 0.115)82.2 ± 39  (P = 0.156)179 ± 13  (P = 0.188)11.4 ± 0.9  (P = 0.853)
6 wk
 C57BL/6J27 ± 240 ± 9109 ± 19428 ± 61169 ± 18
 β2−/−25 ± 3  (P = 0.270)44 ± 3  (P = 0.351)106 ± 23  (P = 0.410)258 ± 37  (P < 0.05)159 ± 26  (P = 0.0240)
8 wk
 C57BL/6J51 ± 730 ± 975 ± 16121 ± 20181 ± 27
 β2−/−35 ± 5  (P < 0.05)66 ± 8  (P < 0.05)84 ± 8  (P = 0.235)118 ± 9  (P = 0.634)159 ± 31  (P = 182)
  • a Cytokines were measured in the supernatants of splenic cells 24 h after being cultured in vitro.

  • b P values are for comparisons between mouse strains.