Table 2.

GalN effects on lethality of treponeme infection in mice

Treponeme strainaGalNbTreponeme doseLethalityc
T. denticolaGM-1+1071/5
+1081/5
+1094/4
+10105/5
1090/5
10100/5
T. denticola 35404+1094/5
+10105/5
1090/5
10100/5
T. pectinovorum S1+1070/5
+1080/5
+1098/10
+101010/10
1070/5
1080/5
1090/5
10100/5
T. pectinovorum 33768+1095/5
+10105/5
1090/5
10100/5
None+0/5
  • a T. denticola GM-1 was tested in BALB/c mice; all other strains were tested in ICR mice and provided comparable results irrespective of the mouse strain used.

  • b GalN was mixed with an appropriate concentration of treponemes and administered i.p. to groups of mice. Control animals received either GalN or an appropriate concentration of treponemes i.p.

  • c Number of animals that died/total number of animals infected.